Polymerase Chain Reaction (PCR)Polymerase Chain Reaction (PCR) turns a tiny bit of DNA into a much larger amount which can subsequently be sequenced. In 1983, Mullis figured out a way to multiply the tiniest piece of DNA by orders of magnitude, making millions of copies. This is how the smallest bit of DNA, from bacteria, viruses, historical artifacts, … Continue reading "Polymerase Chain Reaction (PCR)"
Shareholder Value Theory: Milton Friedman ReduxOn September 13, 1970, Milton Friedman published one of the most arguably economically destructive articles in history, “The Social Responsibility Of Business Is to Increase Its Profits,” in the New York Times. The article is available, in PDF form, for subscribers from the New York Times website. Friedman advanced the idea that managers are agents … Continue reading "Shareholder Value Theory: Milton Friedman Redux"
Surgical DisinfectantSurgical disinfectant vastly reduces the risk of infection and subsequent disease and death. Lister, building on the work of Pasteur and Semmelweis, insisted that surgery and surgical equipment be cleaned with carbolic acid, an early attempt at sterilization. Before Lister, surgeons would not change their clothes: more blood showed more experience. Semmelweis advanced similar ideas, … Continue reading "Surgical Disinfectant"
Long-Term MortgagesMortgages are loans to purchase a property. The word derives from the French “mort” and meant death pledge with the obligation ending when the loan was paid off or the property repossessed. Background The Dutch have the earliest mortgages. Originally in the Netherlands, people saved money and purchased their house for cash. However, starting in … Continue reading "Long-Term Mortgages"
Personal Computer, Xerox Alto (the “interim Dynabook”)Dynabook was at the heart of Xerox PARC. Eventually realized as the Xerox Alto, it is essentially the first personal computer. Easy-to-use with a graphical interface, what-you-see-is-what-you-get (WYSISYG) programs, icons, the mouse, networking. Everything we take for granted today started as the Dynabook/Alto. Background The Dynabook dates to Kay’s doctoral thesis and the first interview … Continue reading "Personal Computer, Xerox Alto (the “interim Dynabook”)"
Core MemoryCore memory enhanced the productivity of early computer operators. Not only does core memory store information but also does not need power to maintain memory. Wang & Woo created computer memory that would sit on tiny magnetic rings, strung together into cores. These were smaller than vacuum tubes and used less power. Furthermore, they did … Continue reading "Core Memory"
Spread Spectrum Frequency Hopping1941 Hedwig Eva Maria Kiesler (Hedy Lamarr)George Antheil Spread spectrum frequency hopping synchronizes devices to speak over changing frequencies. The technology jumps from one frequency to another in a predetermined but predictable manner so that the sender and recipient can change simultaneously. Lamarr and Antheil created the technology to contribute to the WWII effort, though … Continue reading "Spread Spectrum Frequency Hopping"
JukeboxThe Jukebox is an automated coin-operated music player which plays individual songs. The differentiating factor of the Jukebox from a simple coin-operated record player is the ability of an automated machine to replace live music in a restaurant or bar. Background Louis Glass and William Arnold modified Edison’s record players to operate by coins. These … Continue reading "Jukebox"
LithographyLithography allows highly detailed drawings to be inexpensively reproduced at high volumes. Before lithography, printing remained similar from Gutenberg until Senefelder’s lithographic process. Senefelder worked as an actor and playwright. Unable to earn a living, he turned to printing as a trade but could not afford the typographic fonts and materials. Frustrated, he started experimenting … Continue reading "Lithography"
PasteurizationFrench scientist Louis Pasteur disproved the theory of spontaneous generation, the idea that certain organisms are ever-present in nature. For example, early scientists believed fleas came from dust and maggots from dead meat absent anything else. Pasteur theorized and later proved that all organisms come from something else, that nothing exists in a vacuum. He … Continue reading "Pasteurization"
VideoconferencingVideoconferencing is well over 50 years old. Today, it is fast and virtually free over the Internet. However, aside from extremely formal or informal events, videoconferencing has largely failed to catch on. Background AT&T introduced videoconference at the 1964 World’s Fair. People in New York waited in line to walk into a booth and spend … Continue reading "Videoconferencing"
High-Yield Rice (IR8)Asia was on the edge of an epic famine large enough to cause widespread death and civil unrest. Both the Ford and Rockefeller Foundation responded by founding and funding a thinktank to create higher-yield rice, the International Rice Research Institute (IRRI). Straightaway, they sent a team of mainly American scientists to research if anything could … Continue reading "High-Yield Rice (IR8)"
LASERLASER’s allow light to be intensely focused. There are many uses, from reading digital media at low power to cutting at higher powers. Countless applications rely on LASER technology. In 1957, Arthur Schawlow and Charles Townes, of Bell Labs, worked on an infrared LASER, called an “optical MASER.” They patented the invention in 1958. In … Continue reading "LASER"
Postal System1497 Franz von TaxisHenry BishopRowland HillWilliam Dockwra Franz von Taxis created the postal system, with regular routes between far-flung cities throughout Europe. Eventually, von Taxis mail routes included mail delivery between Brussels and: Innsbruck, 5.5 days (6.5 days winter) Paris, 44 hours (54 hours winter) Blois, 2.5 days (3 days winter) Lyon, 4 days (5 … Continue reading "Postal System"
Microwave OvenPercy Spencer is a self-taught engineer who did not finish even primary school. He self-taught himself math, science, and electrical engineering while standing guard on ships in the Navy. Before, during, and after WWII, Spencer worked on top-secret magnetrons, the high-powered electrical devices at the heart of a RADAR system. One day he noticed that … Continue reading "Microwave Oven"